At this time there are no known biotin drug interactions where biotin would impact a drug’s effectiveness. There does exist a potential for certain drugs to cause a biotin deficiency or insufficiency. These include antibiotics and seizure medications. Full biotin deficiency is rare because in healthy persons our intestinal bacteria produce it in excess of the body's daily requirements, which is only about 30-100mcgs/day. Antibiotics can kill both bad and good bacteria, so theoretically prolonged use may decrease our necessary intestinal bacteria, thus requiring all biotin needs to be supplied through diet or supplements.